Performance evaluation of the ISO 18363-4:2021 method for quantitative determination of chloropropanediols and glycidol in fats and oils by GC-MS/MS
A new GC-MS/MS method from the ISO 18363 series of standards for determination of fatty acid bound chloropropanediols and glycidol was assessed for its performance characteristics. This method enables indirect simultaneous determination of free 2-monochloropropane-1,3-diol (2-MCPD), 3-monochloropropane-1,2-diol (3-MCPD) and glycidol in a single sample preparation and analysis protocol. Results of the validation study show satisfactory performance characteristics, well within required limits. Recently held proficiency testing also showed the adequate performance of the laboratories employing this method. Taking into consideration the simpler sample preparation and stringent quality control inherent to this protocol, wider use of ISO 18363:4:2021 for routine applications can be expected in the foreseeable future.